The concomitant use of non-steroidal anti-inflammatory drugs (NSAIDs) and Plavix should be avoided as it can cause occult gastrointestinal blood loss. The co-administration of Plavix and warfarin should be done with caution, as there is a risk of increased bleeding.

Plavix should be used with caution in patients with renal or hepatic impairment. Plavix should not be administered to pregnant women. If it is an absolute must to take Plavix during pregnancy, it should be administered under the supervision of a medical practitioner. Plavix should not be administered to nursing mothers and in pediatric patients. Plavix is contraindicated in patients with peptic ulcer or intracranial hemorrhage.