Plavix: review of the medicine

Plavix: review of the medicinePlavix is a medicine based on the active substance called Clopidogrel. Clopidogrel belongs to the antiplatelet class of medicines, used to inhibit blood clots formation in coronary artery disease, peripheral vascular disease, and cerebrovascular disease.

Plavix is a brand name of the medicine owned by Bristol-Myers Squibb and Sanofi-Aventis. Clopidogrel is also supplied under other brand names, as when it is manufactured by other pharmaceutical companies it can be sold under the brand name which belongs to Bristol-Myers Squibb and Sanofi-Aventis. The medicines which are based on Clopidogrel but are called differently are called generic Clopidogrel or generic Plavix. Generics are much cheaper as their brand names are not that widely advertised. However there is a difficulty in their purchase: you hardly can find generic Clopidogrel or generic Plavix at a conventional drug store. However you can greatly save your money buying generic Clopidogrel or generic Plavix at online pharmacy. Our online pharmacy offers you the best prices and best generics of Clopidogrel and Plavix.

When Plavix (Clopidogrel) is prescribed?

Plavix (Clopidogrel) is used for the prevention of platelets formation. Platelets are small blood cells which stick together during blood clotting. This process is called thrombosis. Plavix prevents thrombosis, and is prescribed for the prevention of stroke, heart attack, and other heart diseases that can lead to death.

Your doctor as well may prescribe you Plavix (Clopidogrel) for the treatment of other diseases, if he thinks that the medicine is appropriate for their treatment.

Before you start to use Plavix (Clopidogrel)

When your doctor prescribes you Plavix (Clopidogrel), he will ask you several questions regarding your health. You must not hide anything from your doctor, as if you will not say, for example, that you have kidney problems he will prescribe you a bigger dose of Plavix (Clopidogrel), and you will have problems with your kidney. Before your doctor prescribes you Plavix (Clopidogrel), you should inform him about the following:

  • If you are allergic to Clopidogrel or any drug that has in its compound Clopidogrel
  • If you are pregnant, breastfeeding or plan to become pregnant or breastfeed in near future
  • You plan to have an operation, including dental surgery, in near future
  • If you have some chronic diseases. Especially it is very important to inform your doctor if you have any blood disorders.
  • If you are taking some other medicines at the moment

Pharmaceutical form of Plavix (Clopidogrel)

Plavix (Clopidogrel) is supplied in a form of oral pills by 75 mg and 300 mg.

Dosage of Plavix (Clopidogrel)

The dosage of Plavix (Clopidogrel) is prescribed individually by a doctor.

However there are regular doses:

  • The usual dose of Plavix is one 75 mg tablet daily.
  • For the treatment of Acute Coronary Syndrome is prescribed 300mg of Plavix daily. Over time the, the dose may be decreased to 75 mg of Plavix (Clopidogrel) daily.

Plavix (Clopidogrel) can be taken both before and after meal. You should swallow entire pill, without chewing or crushing it. The tablet should be washed down with a full glass of water.

Contraindications for Plavix (Clopidogrel) use

Plavix (Clopidogrel) is contraindicated to people with

  • Hypersensitivity to the drug ingredients
  • Active bleeding
  • Gastrointestinal bleeding
  • Intracranial hemorrhage

Side effects of Plavix (Clopidogrel)

As any medicine, Plavix (Clopidogrel) may cause the appearance of some side effects, the most common ones are:

  • dyspepsia
  • diarrhea
  • nausea
  • abdominal pain
  • hemorrhage
  • purpura
  • rash
  • pruritus
  • dizziness
  • headache
  • fatigue

There are also some side effects, which occur very rare, but in occurrence of which you should immediately seek professional medical assistance:

  • hemorrhage
  • bleeding
  • Thrombotic purpura
  • neutropenia
  • serum sickness
  • angioedema
  • Stevens-Johnson syndrome (symptoms: fever general ill feeling, tching of the skin, joint aches, multiple skin lesions)
  • toxic epidermal necrolysis
  • acute hepatic failure
  • pancreatitis

Where to buy Plavix (Clopidogrel)?

If you have a prescription for Plavix (Clopidogrel) from your doctor, you can buy Plavix (Clopidogrel) virtually at any drug store. But if you want to save your money, the best option for you is to buy Plavix (Clopidogrel) online from an online pharmacy.

Why Plavix (Clopidogrel) is cheaper at online pharmacy?

First of all, online pharmacies have less operational costs than conventional drug stores. Secondly, most of online pharmacies, including our online pharmacy, sell not only medicines with advertised brand names, but also their generics which are not inferior but are much cheaper. Thirdly, such online pharmacies as ours work directly with the manufacturers of the medicines, avoiding middlemen, which eventually allows us to offer lower prices.

If you want to have an effective treatment with Plavix (Clopidogrel), and do not spend a lot of money, buy Plavix (Clopidogrel) online from our online pharmacy.

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Difference between Brand and Generic Clopidogrel

The active ingredient is Clopidogrel in both brand and generic forms. The mechanism of action and effectiveness is same for both generic and brand forms. The difference between brand and generic forms are packaging, pricing and the brand name. You can buy cheap Plavix pills when it is sold as a generic variant.

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What are the common dosages of generic Plavix?

The recommended starting dosage of Plavix is 75 mg once daily. In non ST segment elevation acute coronary syndrome single loading dose of 300mg is given followed by 75mg once daily. In ST segment elevation acute coronary syndrome 75mg once daily is given.

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Guidelines before using Plavix

The concomitant use of non-steroidal anti-inflammatory drugs (NSAIDs) and Plavix should be avoided as it can cause occult gastrointestinal blood loss. The co-administration of Plavix and warfarin should be done with caution, as there is a risk of increased bleeding.

Plavix should be used with caution in patients with renal or hepatic impairment. Plavix should not be administered to pregnant women. If it is an absolute must to take Plavix during pregnancy, it should be administered under the supervision of a medical practitioner. Plavix should not be administered to nursing mothers and in pediatric patients. Plavix is contraindicated in patients with peptic ulcer or intracranial hemorrhage.

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Side Effects of Plavix

The common side effects reported with Plavix are chest pain, influenza like symptoms, pain, fatigue, edema, hypertension, head ache, dizziness, abdominal pain, dyspepsia, diarrhea, nausea, hypercholesterolemia, back pain , purpura, depression, upper respiratory tract infection, bronchitis, coughing and urinary tract infection.

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How does Plavix work?

Plavix causes sticking of platelets to the damaged vessel wall and it aggregates to form a platelet plug. The platelet plug releases ADP and thrombaxane A2. In veins due to the sluggish blood flow a fibrinous tail is formed that traps RBCs and in arteries the thrombus is due to platelet plug. Plavix alters the receptors on platelets and inhibits ADP and fibrinogen induced platelet aggregation. The purinergic receptors which mediate adenylyl cyclase inhibition by ADP are blocked by Plavix. This prevents activation of platelets. Plavix also prevents fibrinogen binding to platelets but does not affect TXA2.

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Plavix (Clopidogrel)

Plavix is a prodrug that interferes with platelet function and is useful in the prophylaxis of thromboembolic disorders. Antiplatelet drugs like Plavix are more useful in arterial thrombosis, while anticoagulants are more effective in venous thrombosis.Plavix prolongs the bleeding time and increases the platelet survival in extracorpeal circulation. Generic variants of Plavix are also available now. You can buy Plavix online from our pharmacy.

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